| Irinotecan |
|
| Name: Irinotecan |
| Syn: CPT-11; Camptosar, Camptothecan-11 |
| CAS No.: 97682-44-5 |
Brief introduction:
Irinotecan is a water soluble, semi-synthetic analogue of 20(S) camptothecin (CPT) with promising activity against a range of tumour types. Irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks.
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| molecular formula: C33H38N4O6 |
| Molecular weight: 586.69(anhydrous) |
| Structure: |
|
Property:
yellow crystal,insoluble in water,its sodium salt is
the water-soluble,its organic solution has blue fluorescence.Melting point:
268-270¡æ
|
Source:
Isolated from Camptotheca acuminata or semisynthesis
from camptothecin.Pharmacological activity: Hydroxycamptothecin possesses
anti-cancer activity.
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Quality Standard:
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| Inspection item | Specification |
| Appearance | Pale-yellow powder |
| Melting point | 222-223¡æ |
| Loss on drying | <3% |
| Heavy metals | <10 ppm |
| Assay(By HPLC) | >98% |
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